Supplementary Figure 3: Syncrip-deleted hematopoietic cells retain colony-forming and in vivo engraftment capacity. | Nature Genetics

Supplementary Figure 3: Syncrip-deleted hematopoietic cells retain colony-forming and in vivo engraftment capacity.

From: Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

Supplementary Figure 3

(a) Representative PCR analysis for genotyping of Syncrip deletion in fetal liver cells. (b) Quantitative summary of FACS analysis of hematopoietic stem and progenitor cells in the WT and Syncrip-CR-KO fetal livers in Figure 3c (WT n = 7, CR-KO n = 7). (c) Quantitative summary of the number of all colony types formed by WT and Syncrip-CR-KO fetal liver cells (average of six biological samples). BFU-E, burst-forming unit–erythroid; M, macrophage; G, granulocyte; GM, granulocyte, macrophage; GEMM, granulocyte, erythroid, macrophage, megakaryocyte. (d) Assessment of disease burden, including spleen weight and liver weight, for the recipient mice in Figure 3j. *P < 0.05, two-tailed t test.

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