Supplementary Figure 5: Elevated expression of SYNCRIP correlates with expression profiles of the HOXA9 and MEIS1 target genes IKZF2 and MYC in patients with AML. | Nature Genetics

Supplementary Figure 5: Elevated expression of SYNCRIP correlates with expression profiles of the HOXA9 and MEIS1 target genes IKZF2 and MYC in patients with AML.

From: Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells

Supplementary Figure 5

(a) Plots showing the distribution of mean normalized counts of KD1 correlating with normalized mean counts of KD2 from the RNA sequencing data in Figure 5a. (b) Normalized read counts of Syncrip, Hoxa9, Myc, Ikzf2 and Meis1 from the RNA sequencing data in Figure 5a. (c–f) log2 mRNA levels of the indicated genes in patients with high versus low SYNCRIP mRNA expression in the data sets for patients with AML reported in Figure 4a (high SYNCRIP was defined as individuals with a value greater than the average + 1 s.d. while low SYNCRIP was defined as individuals with a value greater than the average – 1 s.d.). (c) MSI2 mRNA. (d) Target genes upregulated by HOXA9–MEIS1. (e) Target genes downregulated by HOXA9–MEIS1. (f) IZKF2 mRNA. (g) MYC mRNA. *P < 0.05, **P < 0.01, ***P < 0.001, two-tailed t test.

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