Supplementary Figure 5: GATA3 binds to the epicenters of super-enhancers of ADRN-specific TFs.
From: Neuroblastoma is composed of two super-enhancer-associated differentiation states
(a) The most prominent GATA3 binding peak19 within super-enhancers of ADRN super-enhancer-associated TFs was used to center a ±1-Mb region. Data are from cell line SH-SY5Y. Gene bodies within the region are indicated in thin stripes, and signature TFs are indicated with thick stripes. The blue dot indicates GATA3, zoomed in c. (b) The same regions are shown, now showing the H3K27ac signal19. (c) Example of the GATA3 and H3K27ac profiles in the region of the GATA3 gene and its associated super-enhancers. The zoomed region shows that GATA3 peaks binds to the epicenter of the H3K27ac domains.
