Supplementary Figure 10: Mesenchymal neuroblastoma cells are chemo-resistant in vitro and are enriched in post-therapy tumors in vivo. | Nature Genetics

Supplementary Figure 10: Mesenchymal neuroblastoma cells are chemo-resistant in vitro and are enriched in post-therapy tumors in vivo.

From: Neuroblastoma is composed of two super-enhancer-associated differentiation states

Supplementary Figure 10

(a) Box plots showing sensitivity to cisplatin, doxorubicin or etoposide of pairs of MES- and ADRN-type cells of isogenic origin. MTT assays were used to determine viability after cisplatin, doxorubicin or etoposide treatment. MES- and ADRN-type cells in orange and blue, respectively. Whiskers denote the interval within 1.5 times the interquartile range (IQR) of the median. (b) IHC analysis of the mesenchymal marker PRRX1 in tumor biopsies taken before and after chemotherapy treatment (patients 1 and 2) or after treatment (patients 3 and 4). Scale bar, 50 μm.

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