Supplementary Figure 2: Spontaneous in vitro interconversion and in vivo tumorigenicity of MES and ADRN cells.

(a) Frequency of CD133⁺ cells in clones grown from FACS-sorted CD133^– AMC700B cells. (b) Survival of mice xenografted with FACS-sorted CD133⁺ or CD133^– cells of cell line AMC700B. Mice were sacrificed when tumors were up to 1 cm in diameter. (c) IHC analysis of the tumors grown from xenografted CD133⁺ or CD133^– 700B cells. Tumors were stained for dopamine β-hydroxylase (DBH) and vimentin (VIM). HE, hematoxylin and eosin staining.