Supplementary Figure 6: Distribution of the candidate genes over the identified molecular subtypes. | Nature Genetics

Supplementary Figure 6: Distribution of the candidate genes over the identified molecular subtypes.

From: Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma

Supplementary Figure 6

Bar plots indicating the distribution of all candidate genes over the molecular subtypes. Red bars indicate significant associations between candidate genes and the corresponding molecular subtype (FDR < 0.1, one-sided Fisher’s exact test with Benjamini–Hochberg correction). (a,b) This analysis was performed for both the set of 99 tumors with an ILC morphology (a) and the full set of 123 tumor samples (to increase statistical power) (b). The latter analysis identified an additional enrichment for Trps1 in the combined mILC-1 and mILC-2 subtypes, suggesting that Trps1 may play a role in the ILC morphology of these tumors. Additionally, the mILC-2 subtype was further enriched for insertions in Arid1a and Rasgrf1, indicating that expression differences between mILC-1 and mILC-2 may in part be driven by insertions in these genes.

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