Supplementary Figure 11: Expression of truncated Ppp1r12a/b and Trp53bp2 and PPP1R12A protein expression in SB-induced tumors. | Nature Genetics

Supplementary Figure 11: Expression of truncated Ppp1r12a/b and Trp53bp2 and PPP1R12A protein expression in SB-induced tumors.

From: Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma

Supplementary Figure 11

(a–c) Truncated Ppp1r12a/b and Trp53bp2 in SB-induced tumors, as visualized by northern blot analysis. (d) Expression of PPP1R12A in SB-induced tumors with and without insertions in Ppp1r12a, as visualized by immunoblotting using an anti-PPP1R12A antibody. β-actin is shown as a loading control. (e) Coimmunoprecipitation of PP1 in HC11 cells expressing GFP, truncated PPP1R12A or TRP53BP2, as visualized by immunoblotting using anti-FLAG and anti-PP1 antibodies.

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