Supplementary Figure 1: Survival curves for the individual T2/Onc transgenic mouse lines, distribution and immunohistochemical stainings of the different tumor morphologies. | Nature Genetics

Supplementary Figure 1: Survival curves for the individual T2/Onc transgenic mouse lines, distribution and immunohistochemical stainings of the different tumor morphologies.

From: Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma

Supplementary Figure 1

(a) Survival curves Wap-Cre;Cdh1F/F;SB mice carrying the T2/Onc transposon donor loci on chromosomes 1 and 15 (n = 142 and n = 126 mice, respectively). ns, no significant difference (Mantel–Cox test). (b) Tumor morphologies of Wap-Cre;Cdh1F/F (n = 16) and Wap-Cre;Cdh1F/+;SB (n = 4) female mice. (c) Immunohistochemical detection of E-cadherin, cytokeratin 1, cytokeratin 8 and vimentin in the different tumor morphologies. Scale bar, 50 μm.

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