Supplementary Figure 7: Analyses of gene expression associated with the rs12493885 alleles. | Nature Genetics

Supplementary Figure 7: Analyses of gene expression associated with the rs12493885 alleles.

From: Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

Supplementary Figure 7

(a) eQTL analysis. In 133 coronary artery samples obtained by GTEx, eQTL analysis does not demonstrate evidence of altered expression associated with the ARHGEF26 p.Val29Leu (rs12493885) variant. β = 0.22, P = 0.16. No other variants in the region demonstrate significant eQTL effects at a threshold of FDR < 0.05 in coronary artery. The β estimate is aligned to the C (Leu29) allele. (b) Allele-specific expression analysis. In 20 coronary artery samples obtained from the GTEx Consortium heterozygous for the ARHGEF26 p.Val29Leu (rs12493885) variant, no individual demonstrated significant evidence of allele imbalance in coronary artery at a threshold of FDR < 0.05 (n.s., two-sided binomial test non-significant). REF refers to the reference (G, Val29) allele and ALT to the alternative (C, Leu29) allele.

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