Supplementary Figure 8: COREs surround prostate master transcription factors, and CORE deregulation in T2E prostate cancer corresponds to T2E-specific gene expression changes. | Nature Genetics

Supplementary Figure 8: COREs surround prostate master transcription factors, and CORE deregulation in T2E prostate cancer corresponds to T2E-specific gene expression changes.

From: TMPRSS2–ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer

Supplementary Figure 8

Snapshot depicting H3K27ac ChIP-seq signal in T2E and non-T2E primary prostate cancer for (a) FOXA1 and (b) HOXB13. (c) Volcano plot of log2 fold change vs -log2 FDR-corrected q-value for statistical significance of differential expression from MSKCC dataset of all genes that were overlapping a T2E-up or T2E-down CORE.

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