Supplementary Figure 9: CRISPR-mediated deletions of the TMPRSS2–ERG CORE. | Nature Genetics

Supplementary Figure 9: CRISPR-mediated deletions of the TMPRSS2–ERG CORE.

From: TMPRSS2–ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer

Supplementary Figure 9

(a) Snapshot depicting H3K27ac ChIP-seq signal in primary tumors, VCaP cells, and HUVEC cells as well as master transcription factor binding in VCaP cells across the control AAVS1 locus in the PPP1R12C gene. (b) PCR blots to verify deletions of EC1, EC2, EC3, and control loci. PCR products running below expected size products represent deletion fragments. (*: non-specific PCR product).

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