Supplementary Figure 11: Proposed model for the role of Lgr6 in tumor fate decisions.
From: Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma
Lgr6+ stem cells in the skin are capable of giving rise to progeny that differentiate down either the epidermal or hair follicle lineage. Within these stem cells, Lgr6 positively regulates Wnt signaling and serves to restrain commitment down the epidermal lineage.
