Supplementary Figure 11: BAF47 rescue increases BAF complex occupancy at bivalent promoters and significantly reduces H3K27me3 occupancy. | Nature Genetics

Supplementary Figure 11: BAF47 rescue increases BAF complex occupancy at bivalent promoters and significantly reduces H3K27me3 occupancy.

From: SMARCB1 is required for widespread BAF complex–mediated activation of enhancers and bivalent promoters

Supplementary Figure 11

(a) Overlap of BAF155, SS18, and BAF200 target genes in empty and BAF47 conditions in TTC1240. (b) Distribution of BRG1 target genes in empty and BAF47 conditions, with y-axis indicating proportion of all genes in each category. (c) Metagene plots for BRG1, H3K27me3, and Input over all TTC1240+BAF47 BRG1-BAF155 sites. (d-e) Metagene plots of BRG1-BAF155 sites in TTC1240+BAF47 split by (left) promoter-proximal (≤2kb from TSS) and (right) promoter-distal (>2kb from TSS) for (d) H3K27me3, and (e) SUZ12 occupancy. (f) Metagene plot over all 3512 bivalent promoters in TTC1240 for BAF155, SUZ12, and input. (g-i) Correlation plot of log2(fold change) for (g) BRG1, (h) SS18, or (i) BAF200 vs. H3K27me3 over promoter-proximal BRG1-BAF155 sites in empty or BAF47 conditions in TTC1240 cells.

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