Supplementary Figure 14: H3K27ac HiChIP fine-mapping of GWAS variants in haplotype blocks. | Nature Genetics

Supplementary Figure 14: H3K27ac HiChIP fine-mapping of GWAS variants in haplotype blocks.

From: Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

Supplementary Figure 14

(a) Global validation of HiChIP signal at putatively causal SNPs versus corresponding SNPs in LD (r2 ≥ 0.8) for naive and Treg cell subtypes. SNP–TSS pairs were generated from published fine-mapped data sets, in comparison to a distance-matched SNP–TSS pair set in the same LD block. (b) Interaction profile of the SATB1 promoter, and a 1-kb resolution visualization of the SNP-containing enhancer of interest. Differences in EIS bias between 5-kb and 1-kb resolution reflect high signal in a single 1 kb bin in TH17 cells around the SATB1 TSS and specific SNPs within the enhancer. LD SNPs (r2 ≥ 0.8) correspond to GRASP SNPs (genome-wide significance P < 10−8). The highlighted SNP is a PICS closest to focal EIS to SATB1.

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