Supplementary Figure 2: Copy number–amplified genes are enriched for depletion ranks in CRISPR–Cas9 essentiality screens. | Nature Genetics

Supplementary Figure 2: Copy number–amplified genes are enriched for depletion ranks in CRISPR–Cas9 essentiality screens.

From: Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

Supplementary Figure 2

(a) A one-sample K-S test is performed on the depletion ranks of the 100 most amplified genes per cell line in each dataset. The K-S enrichment statistic for each line is plotted against the mean copy number of these 100 genes. Red points indicate cell lines for which these 100 genes are significantly enriched at P < 0.05. (b) As in Figure 1d, genes are ranked by average guide score for cell lines screened in two previously published datasets, and the ranks (median and IQR) of the 100 genes with the highest copy number measurements are plotted and colored by their mean copy number.

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