Supplementary Figure 1: Summary of main analyses and key findings.
From: Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
Meta-analysis of GWAS results from 13 studies identified 136 variants independently associated with disease risk at a P < 3 × 10−8, of which 73 were in low LD (r2 < 0.05) with published allergy risk variants. Based on a high LD (r2 > 0.8) between the 136 sentinel risk variants and sentinel cis-eQTLs and/or nonsynonymous coding variants, a total of 132 likely target genes were identified. The likely target genes were preferentially expressed in whole blood and lung, and enriched among pathways related to lymphocyte immunity. Twenty-nine genes are targets of drugs considered for clinical development, including six for which the effect on gene expression of the allergy-protective allele and the respective drug matched. Thirty-six genes have a nearby CpG for which methylation levels are associated with gene expression levels independently of SNP effects on expression and methylation. For one of these genes, variation in methylation levels at the expression-associated CpG was significantly associated with smoking status.
