Supplementary Figure 3: Eighty-nine allergy risk variants (gray bars) in low LD (r2 < 0.05) with each other reported in previous GWAS, according to the year each association was first reported.
From: Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
We identified 185 SNP associations with allergic disease at P < 5 × 10−8 in the NHGRI-EBI GWAS catalog. Correlated SNPs were then grouped based on LD, such that the lead SNP in each group was in LD (r2 > 0.05) with other variants in that group but not with the lead SNPs of all other groups. This procedure is described in greater detail in the Supplementary Note. This resulted in 89 groups of SNPs associated with allergic disease. The earliest year an association was reported with a variant in each group was identified and plotted. The red bar shows the number of novel variants discovered in this study (50 in new loci and 23 in known loci).
