Supplementary Figure 4: Twenty-six of the 136 sentinel variants were significantly associated with variation in the reported age of onset for allergic disease.
From: Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology
We first tested the association between each sentinel variant and the age at which symptoms of any allergic disease (asthma, hay fever or eczema) were first reported, using data from the UK Biobank study (n = 35,972). After correcting for multiple testing, 26 variants (yellow circles) had a significant association with age of onset with the allergy-predisposing allele always associated with decreased age of onset (i.e., a negative β, shown on the y axis). An additional 47 variants (blue circles) were nominally associated (P < 0.05) with age of onset. We then performed the same analysis separately for individuals who reported suffering only from a single disease and formally compared the SNP effects between the three groups. In these analyses, the effect on age of onset was significantly different (P < 0.05) between the three diseases for 8 of the 26 variants (yellow circles with black inner dot), consistent with the presence of disease-specific SNP effects on age of onset.
