Figure 3: Diminished T-cell numbers in lymph nodes from transgenic mice. | Nature Genetics

Figure 3: Diminished T-cell numbers in lymph nodes from transgenic mice.

From: Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Figure 3

Lymph node cells from representative normal littermate controls (NLC), sf mice and the various transgene lines were examined for cell number and phenotype. Total cell number (a) from lymph nodes of transgenic mice are consistently less than that in NLC animals, and the extent of reduction is roughly parallel to transgene expression. The ratio of CD4+8– to CD4–8+ cells in the lymph nodes is altered in high-copy transgenic mice, due in part to a decrease in the percentage of CD4–8+ cells (b). The total number of CD4+8– T cells in the lymph nodes of transgenic mice is less than that of NLC as well as sf animals (c). The alterations in cell numbers are consistent in at least 5 mice per transgenic line analyzed between 4 and 16 weeks of age, and the phenotype remains consistent on backcrossing to C57Bl/6 mice for at least six generations.

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