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Anthrax target in macrophages unveiled

Nature Genetics volume 38, pages 137–138 (2006)Cite this article

Anthrax lethal toxin lyses macrophages derived from certain inbred mice but not others, forming the basis of a bioassay widely used in the development of antibodies and drugs to treat anthrax. A new study identifies two genes essential for this lysis, revealing potential links between toxin-induced proteolysis and cellular killing.

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Figure 1: Model of macrophage killing by anthrax lethal factor.

Katie Ris

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Authors and Affiliations

  1. Proteases and Tissue Remodeling Unit, National Institute of Dental and Craniofacial Research (NIDCR), US National Institutes of Health (NIH),

    Thomas H Bugge & Stephen H Leppla

  2. Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, US NIH, Bethesda, Maryland, USA

    Thomas H Bugge & Stephen H Leppla

Authors
  1. Thomas H Bugge
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  2. Stephen H Leppla
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Bugge, T., Leppla, S. Anthrax target in macrophages unveiled. Nat Genet 38, 137–138 (2006). https://doi.org/10.1038/ng0206-137

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