Two highly penetrant loci have been linked to familial breast cancer (BRCA1 and BRCA2), but do not explain most breast cancer familial aggregation. A new study suggests that a variant in a gene involved in DNA repair may account for some of this unexplained risk.
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Brody, L. CHEKs and balances: accounting for breast cancer. Nat Genet 31, 3–4 (2002). https://doi.org/10.1038/ng0502-3
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DOI: https://doi.org/10.1038/ng0502-3
