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Positioned to expand

Nature Genetics volume 31, pages 5–6 (2002)Cite this article

The position of trinucleotide repeats relative to adjacent origins of DNA replication can drastically affect repeat expansion. This finding offers insight into the cause of several hereditary diseases in humans.

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Figure 1: Models of TNR expansion by replication.
Figure 2: Possible mechanisms triggering TNR-related diseases.

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Authors and Affiliations

  1. Department of Molecular Genetics, University of Illinois at Chicago, Chicago, 60607, Illinois, USA

    Sergei M. Mirkin & Ekaterina V. Smirnova

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  1. Sergei M. Mirkin
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  2. Ekaterina V. Smirnova
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Mirkin, S., Smirnova, E. Positioned to expand. Nat Genet 31, 5–6 (2002). https://doi.org/10.1038/ng0502-5

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