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Src kinases in Ph+ lymphoblastic leukemia

Nature Genetics volume 36, pages 440–441 (2004)Cite this article

Philadelphia chromosome–positive leukemia may present as chronic myeloid leukemia or B-cell acute lymphoblastic leukemia. A new study shows that certain Src kinases are necessary for the induction of B-cell acute lymphoblastic leukemia but not chronic myeloid leukemia.

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Figure 1: Induction of B-ALL versus CML by Bcr-Abl. p190, the shorter form, is practically restricted to B-ALL, whereas p210 is found in both conditions.

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  1. the Center for Hematological Malignancies, Oregon Health & Science University, Portland, Oregon, USA

    Michael Deininger

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  1. Michael Deininger
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Deininger, M. Src kinases in Ph+ lymphoblastic leukemia. Nat Genet 36, 440–441 (2004). https://doi.org/10.1038/ng0504-440

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