A new study identifies a protective role for cellular aggregates in Huntington disease by showing that aggregates promote the clearance of mutant protein by activating autophagy through the inhibition of mTOR. This challenges the common view that they are possibly innocuous but probably harmful to the host cell.
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References
Ravikumar, B. et al. Hum. Mol. Genet. 11, 1107–1117 (2002).
Klionsky, D.J. & Emr, S.D. Science 290, 1717–1721 (2000).
Liang, X.H. et al. Nature 402, 672–676 (1999).
Ravikumar, B. et al. Nat. Genet. 36, 585–595 (2004).
Rubinsztein, D.C. Trends Genet. 18, 202–209 (2002).
Michalik, A. & Van Broeckhoven, C. Hum. Mol. Genet. 12, R173–R186 (2003).
Yang, W. et al. Hum. Mol. Genet. 11, 2905–2917 (2002).
Yamamoto, A., Lucas, J.J. & Hen, R. Cell 101, 57–66 (2000).
Qin, Z.H. et al. Hum. Mol. Genet. 12, 3231–3244 (2003).
Bjornsti, M.A. & Houghton, P.J. Nat. Rev. Cancer 4, 335–348 (2004).
Kim, D.H. et al. Cell 110, 163–175 (2002).
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Thoreen, C., Sabatini, D. Huntingtin aggregates ask to be eaten. Nat Genet 36, 553–554 (2004). https://doi.org/10.1038/ng0604-553
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DOI: https://doi.org/10.1038/ng0604-553
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The tail domain of PRRSV NSP2 plays a key role in aggrephagy by interacting with 14-3-3ε
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