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Aging counts on chromosomes

Nature Genetics volume 36, pages 672–674 (2004)Cite this article

The acquisition of an abnormal number of chromosomes is a hallmark of many human cancers. A new study indicates that unequal segregation of genetic material to daughter cells during cell division can also lead to premature senescence and accelerated onset of a variety of aging phenotypes.

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Figure 1: The consequences of chromosomal instability.

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Authors and Affiliations

  1. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Oscar Fernandez-Capetillo & André Nussenzweig

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  1. Oscar Fernandez-Capetillo
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  2. André Nussenzweig
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Fernandez-Capetillo, O., Nussenzweig, A. Aging counts on chromosomes. Nat Genet 36, 672–674 (2004). https://doi.org/10.1038/ng0704-672

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