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Shifting insulator boundaries

Nature Genetics volume 36, pages 1036–1037 (2004)Cite this article

A new study shows that poly(ADP-ribosyl)ation of CTCF regulates its activity as a transcriptional insulator without altering its DNA binding properties. This mechanism provides cells with the flexibility to regulate gene expression without altering fundamental epigenetic programs.

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Figure 1: Regulating the insulator activity of the H19 ICR.

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Authors and Affiliations

  1. Laboratory of Mammalian Genes and Development, Building 6B–206, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Sangkyun Jeong & Karl Pfeifer

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  1. Sangkyun Jeong
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  2. Karl Pfeifer
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Jeong, S., Pfeifer, K. Shifting insulator boundaries. Nat Genet 36, 1036–1037 (2004). https://doi.org/10.1038/ng1004-1036

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