The feasibility of high resolution CGH has been recently demonstrated. We designed a DNA chip of arrayed BAC cloned for frequently involved chromosomal regions in head and neck tumours. Our pilot experiments demonstrate that in our hands the method efficiently detects tetrasomy or trisomy. We will show our initial results with DNA extracted from histological sections from a series of selected head and neck archival tumours. Clinical parameters including grade, histological status, survival time and disease-free period are available. Results will be compared with conventionnal CGH on chromosomes. In the near future, this technique could contribute to the genetic profiling of tumours in a pathology department.