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PTPN22 and autoimmune disease

Nature Genetics volume 36, pages 1248–1249 (2004)Cite this article

Protein tyrosine phosphatases (PTPs) have diverse roles as negative regulators of stimulatory signaling cascades and are widely recognized as key to maintaining immune cellular homeostasis. Recent data implicating the PTP Lyp in susceptibility to four autoimmune diseases attests to the biological importance of PTP immune regulatory roles and to the etiologic relatedness of different autoimmune conditions.

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Figure 1: Known and potential sites of Lyp activity.

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Authors and Affiliations

  1. Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada

    Katherine A Siminovitch

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  1. Katherine A Siminovitch
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Siminovitch, K. PTPN22 and autoimmune disease. Nat Genet 36, 1248–1249 (2004). https://doi.org/10.1038/ng1204-1248

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