Abstract
Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma–associated herpesvirus. It is characterized by the expression of lymphatic lineage–specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma–associated herpesvirus leads to their lymphatic reprogramming; induction of ∼70% of the main lymphatic lineage–specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.
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References
Chang, Y. et al. Science 266, 1865–1869 (1994).
Schalling, M., Ekman, M., Kaaya, E.E., Linde, A. & Biberfeld, P. Nat. Med. 1, 707–708 (1995).
Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M.C. & Cesarman, E. Nature 385, 347–350 (1997).
Beckstead, J.H., Wood, G.S. & Fletcher, V. Am. J. Pathol. 119, 294–300 (1985).
Jussila, L. et al. Cancer Res. 58, 1599–1604 (1998).
Weninger, W. et al. Lab. Invest. 79, 243–251 (1999).
Skobe, M. et al. J. Invest. Dermatol. 113, 1047–1053 (1999).
Wigle, J.T. et al. EMBO J. 21, 1505–1513 (2002).
Hong, Y.-K. et al. Dev. Dyn. 225, 351–357 (2002).
Petrova, T.V. et al. EMBO J. 21, 4593–4599 (2002).
Hirakawa, S. et al. Am. J. Pathol. 162, 575–586 (2003).
Moses, A.V. et al. J. Virol. 76, 8383–8399 (2002).
Poole, L.J. et al. J. Virol. 76, 3395–3420 (2002).
Tang, J., Gordon, G.M., Muller, M.G., Dahiya, M. & Foreman, K.E. J. Virol. 77, 5975–5984 (2003).
Wang, H.W. et al. Nat. Genet. 37, advance online publication, 27 June 2004 (doi:10:1038/ng1384).
Acknowledgements
We thank L. Janes, L. Nguyen, M. Constant and M. Boisclair for technical assistance; D. Jackson for providing the LYVE-1 antibody; K. Alitalo and T. Petrova for providing the PROX1 antibody; and J. Jung for discussions. This work was supported by the National Institutes of Health, the American Cancer Society, the American Heart Association, and the Cutaneous Biology Research Center through the MGH/Shiseido Agreement.
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Supplementary Fig. 1
Expression of lymphatic-specific and blood vessel-specific genes in human HIV-associated Kaposi's sarcoma. (PDF 129 kb)
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Hong, YK., Foreman, K., Shin, J. et al. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma–associated herpesvirus. Nat Genet 36, 683–685 (2004). https://doi.org/10.1038/ng1383
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DOI: https://doi.org/10.1038/ng1383
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