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Genomic segmental polymorphisms in inbred mouse strains

Nature Genetics volume 36, pages 952–954 (2004)Cite this article

Abstract

By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.

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Figure 1: Chromosomal copy-number profiles of inbred mouse strain 129/Sv relative to strain C57BL/6J.
Figure 2: Copy-number profiles of chromosomes 14 and 7 and FISH validation.

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Acknowledgements

We thank A. Bradley for the mouse hybrid ER3.4 embryonic stem cell line and Q. Li for technical support in BAC array preparation. This work was support in part by the US Department of Energy.

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Author notes

  1. Jiangzhen Li and Tao Jiang: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, Texas, USA

    Jiangzhen Li, Tao Jiang, Leif Peterson, Paul Havlak, Richard Gibbs & Wei-Wen Cai

  2. Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, 94143, California, USA

    Jian-Hua Mao & Allan Balmain

  3. Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, Texas, USA

    Leif Peterson

  4. Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, Texas, USA

    Charles Harris & Pulivarthi H Rao

  5. Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, 77030, Texas, USA

    Paul Havlak & Richard Gibbs

Authors
  1. Jiangzhen Li
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  2. Tao Jiang
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  3. Jian-Hua Mao
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  4. Allan Balmain
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  5. Leif Peterson
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  6. Charles Harris
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  7. Pulivarthi H Rao
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  8. Paul Havlak
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  9. Richard Gibbs
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  10. Wei-Wen Cai
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Corresponding author

Correspondence to Wei-Wen Cai.

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The authors declare no competing financial interests.

Supplementary information

Supplementary Fig. 1

Validation of BAC array detected copy numbr changes by Taqman assays. (PDF 5 kb)

Supplementary Fig. 2

Unsupervised cluster analysis of relatedness between inbred mouse strains. (PDF 230 kb)

Supplementary Table 1

Regions of copy number variations in inbred mouse strains. (XLS 365 kb)

Supplementary Table 2

Regions of copy number variations in inbred mouse strains overlapping with segmental duplications. (XLS 272 kb)

Supplementary Methods (PDF 9 kb)

Supplementary Note (PDF 368 kb)

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Li, J., Jiang, T., Mao, JH. et al. Genomic segmental polymorphisms in inbred mouse strains. Nat Genet 36, 952–954 (2004). https://doi.org/10.1038/ng1417

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