Abstract
The gene ST7 has recently been implicated as the broad-range tumor suppressor on human chromosome 7q31.1. We did not detect somatic mutations in ST7 in any of 149 primary ovarian, breast or colon carcinomas. These data suggest that epigenetic downregulation or haploinsufficiency, rather than somatic genetic alterations, may be the primary mechanism of abrogation of ST7 function in these tumor types.
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Change history
04 March 2003
Added the revised supplementary Table B
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Acknowledgements
We thank W. Phillips (Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia) and N. Hayward (Human Genetics Lab, Queensland Institute Medical Research, Herston, Queensland, Australia) for providing colon and breast cancer DNA samples. We also thank J. Zenklusen for sharing pre-publication results. This work was supported in part by a grant from the Association for International Cancer Research (AICR).
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NOTE: In the Supplementary Information for this paper originally published online, an incorrect file was supplied for Web Table B. We have since replaced it with the correct file.
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Thomas, N., Choong, D., Jokubaitis, V. et al. Mutation of the ST7 tumor suppressor gene on 7q31.1 is rare in breast, ovarian and colorectal cancers. Nat Genet 29, 379–380 (2001). https://doi.org/10.1038/ng784
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DOI: https://doi.org/10.1038/ng784
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