Improper termination of inflammatory signals can contribute to tumorigenesis. Cyld and Itch form an ubiquitin-editing complex that cooperatively downregulates the kinase Tak1 and thereby attenuates downstream activation of the transcription factor NF-κB.
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I.E.W. is an employee of Genentech Inc., a for-profit institution.
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Wertz, I. It takes two to tango: a new couple in the family of ubiquitin-editing complexes. Nat Immunol 12, 1133–1135 (2011). https://doi.org/10.1038/ni.2165
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DOI: https://doi.org/10.1038/ni.2165
