Supplementary Figure 2: Rapamycin enhances protection against a lethal H5N1 infection after intranasal infection with LAIV. | Nature Immunology

Supplementary Figure 2: Rapamycin enhances protection against a lethal H5N1 infection after intranasal infection with LAIV.

From: The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

Supplementary Figure 2

C57BL/6 mice received 75 μg/kg rapamycin or PBS, i.p. beginning 1 day prior to and daily for 28 days after primary intranasal infection with 106 TCID50 of a temperature sensitive strain of A/Hong Kong/1/68. On day 28, mice were challenged with 4.5 x 105 EID50 of ΔVn1203 i.n. and monitored for weight loss (*P < 0.05 and **P < 0.01, Two-way ANOVA with Bonferroni multiple comparison, n = 16 per group). Data are representative of 2 independent experiments.

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