Supplementary Figure 6: Hes1-mediated constraint of myeloid gene expression programs is essential for T cell development; the thymus is settled by a myelo-lymphoid progenitor from the bone marrow. | Nature Immunology

Supplementary Figure 6: Hes1-mediated constraint of myeloid gene expression programs is essential for T cell development; the thymus is settled by a myelo-lymphoid progenitor from the bone marrow.

From: T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1

Supplementary Figure 6

Early thymic progenitors (ETP) develop under the influence of Notch signaling in the thymus. Shortly after thymic entry, Notch induces the expression of the transcriptional repressor Hes1, which directly inhibits C/EBP-α, a critical myeloid regulator and perhaps other myeloid lineage genes. Hes1 is expressed in CD4/CD8 double-negative (DN) thymocytes, including ETP, DN2, and DN3 progenitors, but is no longer expressed at the CD4/CD8 double-positive (DP) stage. DN3 and DP thymocytes are committed to the T-cell lineage.

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