Supplementary Figure 6: Transcriptome analysis of carotid injury model.

Transcriptome data derived from RNA of carotid arteries of mice subjected to endothelial injury 3 h prior to HDL (20 ug/kg) or PBS i.v. injection. a Hierarchical clustering of the 2073 most variable genes within the dataset. b, Network visualisation of Gene ontology enrichment analysis (GOEA) based on transcripts regulated in macrophages in vitro and in carotid arteries in vivo. Enrichment scores of GO-terms based on genes upregulated or downregulated by HDL in vivo. a, b, At least three biological replicates per condition were generated and analysed.