Gene-expression signatures of the human vaccine response can be complex and noisy. Li et al. develop a new collection of gene-expression modules and use it to compare the response to five different vaccines.
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References
Querec, T.D. et al. Nat. Immunol. 10, 116–125 (2009).
Gaucher, D. et al. J. Exp. Med. 205, 3119–3131 (2008).
Nakaya, H.I. et al. Nat. Immunol. 12, 786–795 (2011).
Tan, Y. et al. Eur. J. Immunol. doi:10.1002/eji.201343657 (29 November 2013).
Li, S. et al. Nat. Immunol. 15, 195–204 (2014).
Ravindran, R. et al. Science doi:10.1126/science.1246829 (5 December 2013).
Haining, W.N. & Wherry, E.J. Immunity 32, 152–161 (2010).
Hartwell, L.H., Hopfield, J.J., Leibler, S. & Murray, A.W. Nature 402, C47–C52 (1999).
Segal, E. et al. Nat. Genet. 34, 166–176 (2003).
Mootha, V.K. et al. Nat. Genet. 34, 267–273 (2003).
Wagner, G.P., Pavlicev, M. & Cheverud, J.M. Nat. Rev. Genet. 8, 921–931 (2007).
Obermoser, G. et al. Immunity 38, 831–844 (2013).
Shen-Orr, S.S. et al. Nat. Methods 7, 287–289 (2010).
Amit, I. et al. Science 326, 257–263 (2009).
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Haining, W. Strength in numbers: comparing vaccine signatures the modular way. Nat Immunol 15, 139–141 (2014). https://doi.org/10.1038/ni.2807
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DOI: https://doi.org/10.1038/ni.2807
