Supplementary Figure 7: Model for the regulation of TCF-1 by SGK1.
From: The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex
In WT T cells, activation of mTORC2 downstream of TCR signaling results in activation of SGK1. In turn, SGK1 phosphorylates and inhibits GSK-3β. When GSK-3β is inactive, its target β-catenin cannot be degraded. Active β-catenin cooperates with the long isoforms of TCF-1 to promote transcription of TCF-1, which inhibits expression of IFN-γ. In T-Sgk1-/- cells, GSK-3β is active and thus targets β-catenin for destruction. Loss of β-catenin leads to decreased expression of TCF-1 long isoforms, and thus increased expression of IFN-γ.
