Supplementary Figure 5: Ablation of Uhrf1 impairs the expression of functional molecules by Treg cells. | Nature Immunology

Supplementary Figure 5: Ablation of Uhrf1 impairs the expression of functional molecules by Treg cells.

From: The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

Supplementary Figure 5

a, Expression levels of functional molecules by proliferative and non-proliferative Treg cells in cLP. Ki67+ and Ki67- Treg cells from cLP of 16-week-old C57BL/6 Foxp3hCD2 reporter mice were analyzed for CTLA-4, ICOS and GITR expression by flow cytometry. Mean fluorescent intensity (MFI) in each population is shown in the histograms. b, Foxp3+ Treg cells in cLP of Cd4CreUhrf1+/+ (+/+) and Cd4CreUhrf1fl/fl (fl/fl) mice were analyzed for PD-1, ICOS and GITR expression by flow cytometry. Histograms gated on CD3É›+CD4+hCD2+ cells are shown. Data are representative of two independent experiments with similar results.

Back to article page