Supplementary Figure 6: Transcriptome analysis in Zellweger cells.
From: Diverse intracellular pathogens activate type III interferon expression from peroxisomes
Gene expression profiles of Pex19-deficient and reconstituted cells were determined by microarray analysis 9 and 16 hrs after reovirus infection. (A) Table of the most significantly enriched “GO-terms” in regulated genes of Pex19-deficient and reconstituted cells. Pairwise comparisons of both genotypes (B) and time points (C) are depicted in log-log scale scatter plots. The slope of the weighted linear fit indicates stronger gene induction in Pex19-deficient cells (B) and the later time point of infection (C) as the fitted slope is significantly greater than 1. (D) Overview of the 20 most highly upregulated genes in Pex19 reconstituted cells in comparison to Pex19-deficient cells.
