Supplementary Figure 5: IL-2–anti-IL-2 complexes do not 'rescue' autoimmunity in TracFL/FLFoxp3Cre-ERT2 mice.
From: Continuous requirement for the TCR in regulatory T cell function
(a) Schematic of the experimental setup. (b) Percent TCRβ+Foxp3+ (black squares) and total Foxp3+ (white squares) cells among CD4+ cells in lymph nodes of TracWT/WTFoxp3Cre-ERT2 (WT/WT) and TracFL/FLFoxp3Cre-ERT2 (FL/FL) mice treated with IL-2-anti-IL-2 complexes (IL2-c) or PBS. (c,d) CD4+ T cell activation (c) and cytokine production (d) in the spleens of the indicated mice, as in (b). **, P < 0.01; *, P < 0.05. P-values were calculated using a two-tailed unpaired t-test.
