Supplementary Figure 10: Proposed model for the regulation of T cell activation by TRPV1.
From: The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells
TCR stimulation induces the activation of protein tyrosine kinases, such as Lck, which initiate a cascade of phosphorylation events. Our data indicate that TRPV1 is part of this signaling cascade and that tyrosine phosphorylation by Lck is likely the gating mechanism of TRPV1 after TCR stimulation. In addition to CRAC, Voltage-gated Ca2+ channels (CaV) and other TRPs channels, we identified that TRPV1 is required for the proper transduction of TCR induced-Ca2+ influx, TCR-mediated signaling events (for example, MAPKs, NFAT-1 and NF-κB), and downstream activation and acquisition of proinflammatory properties by CD4+ T cells.
