Supplementary Figure 4: Residual responsiveness following in vitro exposure to whole bacteria for C6 modules. | Nature Immunology

Supplementary Figure 4: Residual responsiveness following in vitro exposure to whole bacteria for C6 modules.

From: A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4

Supplementary Figure 4

This box plot displays residual responsiveness of individual patients relative to the average of healthy subjects following 2 hours in vitro exposure to heat killed S. pneumoniae (R11470 and R8450 strains). Red dots = IRAK4-/- patients; Blue triangles = MYD88-/- patients (batch 1 and 2). Modules represented here belong to cluster C6. Figure 6 in the main manuscript show residual responses to S. pneumoniae’s R6 strain and S. aureus.

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