Supplementary Figure 5: Reevaluation of transcriptional responses to TLR agonists and whole bacteria in a new set of patients. | Nature Immunology

Supplementary Figure 5: Reevaluation of transcriptional responses to TLR agonists and whole bacteria in a new set of patients.

From: A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4

Supplementary Figure 5

Blood from healthy controls or patients (combining batch 2 and new set of samples, batch 3) was stimulated in vitro for 2 hours with three strains of heat killed S. pneumoniae and S. aureus and PAM2 (TLR2 agonist); graphs represent overall individual levels of responsiveness in patients relative to the average of control subjects: the number of responsive probes in a given subject / average of differentially expressed probes in healthy controls x 100. No differences are observed in the pattern of responsiveness between batch 2 and 3. Same blunted responses to PAM2 in TIR patients and residual responses to bacteria.

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