Supplementary Figure 1: GPR15 is preferentially expressed on colon CD4+ T cells with a memory/effector (CD45RBlo, CD44hi) and activated phenotype.
From: Role and species-specific expression of colon T cell homing receptor GPR15 in colitis
GPR15 is preferentially expressed on colon CD4+ T cells with a memory/effector (CD45RBlo, CD44hi) and activated phenotype. (a) GPR15 (GFP) expression by memory/effector (CD44hi, CD45RBlo) CD4+ T cells of colon in Gpr15gfp/+ mice. Peripheral lymph nodes (PLN), mesenteric lymph node (MLN), Peyer’s patches (PP), intraepithelial lymphocytes (IEL), lamina propria (LP), small intestine (SI). n = 9, except for colon and SI IELs, where n = 5; mean ± s.e.m. (b) Expression of activation and gut-trafficking molecules on GFP+ CD4+ cells of colon LP (black); CCR9 on GFP+ CD4+ T cells of SI (dashed); (c) cytokines and Treg cell-associated proteins on sorted colon LP GFP+ CD4+ T cells; isotype (gray shade). Representative of 3 experiments.
