Supplementary Figure 1: Induction of Ifnb, Aim2 or Gbp mRNA in dependence of STING and IFNAR signaling. | Nature Immunology

Supplementary Figure 1: Induction of Ifnb, Aim2 or Gbp mRNA in dependence of STING and IFNAR signaling.

From: Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

Supplementary Figure 1

(a) Induction of Ifnb expression from unprimed wild-type (WT), Tlr2–/–, Myd88–/–, Trif–/– and Stinggt/gt bone-marrow derived macrophages (BMDMs) following infection with wild-type F. novicida U112 for 6 h. (b–e) Induction of Gbp2, Gbp3, Gbp5 or Aim2 expression from unprimed wild-type, Tlr2–/–, Myd88–/–, Ifnar1–/– and Stinggt/gt BMDMs following infection with wild-type F. novicida U112 for 6 h. Graphs show mean and s.d. of quadruplicate assays and data are representative of two (b-d) or three (a) independent experiments.

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