Supplementary Figure 2: Foxm1 loss leads to a decreased number of mature blood cells but does not interfere with lineage differentiation. | Nature Immunology

Supplementary Figure 2: Foxm1 loss leads to a decreased number of mature blood cells but does not interfere with lineage differentiation.

From: The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells

Supplementary Figure 2

(a) Histograms represent the total number of myeloid cells (Mac-1+Gr-1+), B cells (B220+ IgM+), Megakaryocyte (CD41+) and Macrophage (F4/80+) in BM from Foxm1fl/fl Tie2-Cre and Foxm1fl/fl mice. Mean ± standard deviation (SD); n = 5. *, P<0.05. (b-e) Representative histograms show the frequency of myeloid cells (Mac-1+Gr+) (b), B cells (B220+IgM+) (c), Megakaryocyte (CD41+) (d) and Macrophage (F4/80+) (e) in BM from Foxm1fl/fl Tie2-Cre and Foxm1fl/fl mice. (f-i) The frequency and representative flow cytometric histograms of four differentiation stages of erythroblasts including R1 (CD71+Ter119–), R2 (CD71+Ter119+), R3 (CD71lowTer119+) and R4 (CD71–Ter119+) in BM cells (f,h) and spleen cells (g,i) from Foxm1fl/fl Tie2-Cre and Foxm1fl/fl mice at age of 6-8 weeks.

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