Supplementary Figure 6: Induction of Foxm1 deletion alters cell-cycle progression in HSCs and HPCs from Foxm1fl/flMx1-Cre mice and chimeric Foxm1fl/flMx1-Cre mice. | Nature Immunology

Supplementary Figure 6: Induction of Foxm1 deletion alters cell-cycle progression in HSCs and HPCs from Foxm1fl/flMx1-Cre mice and chimeric Foxm1fl/flMx1-Cre mice.

From: The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells

Supplementary Figure 6

(a-c) The histograms depicting the cell cycle profile of HPCs (a), LSK cells (b) and LT-HSCs (c) in Foxm1fl/fl Mx1-Cre and Foxm1fl/fl mice (mean±SD, n=3). *, P<0.05, **, P<0.005. (d) The histogram depicting cell cycle status of LSK cells in Foxm1fl/fl Mx1-Cre and Foxm1fl/fl mice (mean±SD, n= 5). *, P<0.05, **, P<0.005. (e-g) The histograms depicting the cell cycle profile of HPCs (e), LSK cells (f) and LT-HSCs (g) in chimeric Foxm1fl/fl Mx1-Cre and Foxm1fl/fl mice (mean±SD, n=5). *, P<0.05; **, P<0.005; ***, P<0.0005. (h) The histogram depicting cell cycle status of LSK cells in chimeric Foxm1fl/fl Mx1-Cre and Foxm1fl/fl mice (mean±SD, n= 5). *, P<0.05; **, P<0.005.

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