Supplementary Figure 8: pDC activation by L-26–human DNA is not dependent on the IL-26 receptor and cytosolic DNA sensing.
From: TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
(a) IFN-α produced by pDCs stimulated overnight with bactDNA or human DNA alone, with IL-26–bactDNA or IL-26–human DNA complexes, or with the STING ligand cGAMP in the presence of 100 ng/ml chloroquine. (b) IFN-α produced by pDCs stimulated overnight with human DNA alone or with IL-26–human DNA complexes in the presence of increasing concentrations of blocking antibodies to IL-10R2. Error bars represent the s.d. of triplicate wells. Data are representative of three independent experiments.
