Supplementary Figure 2: Diminished efficacy of immunization that follows nonspecific inflammation. | Nature Immunology

Supplementary Figure 2: Diminished efficacy of immunization that follows nonspecific inflammation.

From: Conditioning of naive CD4+ T cells for enhanced peripheral Foxp3 induction by nonspecific bystander inflammation

Supplementary Figure 2

(a) Experimental schematic for data described in Figure 2. Briefly, Balb/c mice were treated with pbs or pIC for 2 consecutive days, then on the fourth day after the first treatment, mice were immunized with subcutaneous Ova/IFA. Approximately one week later mice were challenged with Ova either in the in the context of direct intranasal challenge or A20 lymphoma expressing Ova (A20-tGO). See Materials and Methods for detailed description. (b) Mean time of tumor onset, as determined by initial identification of measurable tumor mass following subcutaneous inoculation. Incidence of tumor-bearing mice as a fraction of the total mice in each group is shown below. P-value by one-tailed Mann-Whitney U-test.

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