Supplementary Figure 4: Immunological variation and cocorrelations between individual immune parameters in a replication cohort.

(a) On the replication dataset of 32 English individuals (day 0 sample only), a dendrogram of immune parameters was generated by hierarchical clustering on Euclidean distances of Spearman correlations between each parameter (left). Correlation plots using pairwise Spearman correlation coefficients between each two immunological parameters are shown (right). Coefficients are shown by the angle of eclipse (left-leaning, negative; right-leaning, positive) and colour (blue, negative; red, positive). Manually annotated thematic groups of immune parameters are shown by the colour bar next to the dendrogram.(b) Non-metric multidimensional scaling of pairwise Spearman correlations. The dataset is reduced from 28 immune parameters (28 dimensions) to a 2 dimensional representation, an exploratory approach to investigate the presence or absence of inter-relatedness between immune parameters. Each immune parameter is a point and the thematic groups are highlighted.